Creatine & the Elderly : Part 2

Possible Benefits and Precautions of Creatine Use for the Elderly

The Root of Creatine’s Benefit for the Elderly


  1. Reduced Methylation Status Characterizes Old Age
  2. Creatine Supplementation Enhances Cellular Methylation
  3. Creatine Supplementation May Help Postpone Mental Senescence
  4. Precautions of Creatine Supplementation for the Elderly

Creatine Supplementation May Improve Cellular Methylation Status

The single largest drain of the body’s SAM reserves is the synthesis of creatine. By inference therefore, circumventing creatine synthesis should positively influence an individual’s methylation status. And, the best way to avoid the synthesis of creatine is to provide the body with enough dietary creatine to meet its daily needs, thereby bypassing creatine synthesis altogether. That is, dietary creatine supplementation alleviates the need to synthesize creatine and hence, boosts an individual’s methylation status. Therefore, creatine supplementation contributes to a more healthful methylation status, which, in turn, lays down the foundation for all other anabolic processes in the body.

Moreover, essential B vitamins, namely folic acid, vitamin B12 and vitamin B 6, help regenerate SAM after its consumption in cellular methylation reactions. Therefore, to maximize your methylation potential, include these B-vitamins in your creatine supplementing routine as well.

For those interested, Issue 30 and Issue 31 of the Creatine Newsletter discuss in greater detail the role of creatine supplementation in supporting cellular methylation status.

Creatine Supplementation Reduces Serum Homocysteine Levels

Imbalances in SAM metabolism produce a potentially dangerous molecule known as homocysteine. Typically, homocysteine is either cleared from the body, or reconverted into SAM, with the assistance of B-vitamins. However, elevations in serum homocysteine (as a result of excessive cellular methylation, or B-vitamin deficiencies) have been implicated in many of the most insidious human disorders inflicting the elderly. Therefore, creatine supplementation, by the mere fact that it relieves some of the demand on our endogenous SAM reserves, should help mitigate serum homocysteine levels. In fact, this exact prediction has been borne out in a recent scientific study.

Original Scientific Reference

Creatine Reduces Serum Homocysteine Levels

Below is the reference to the published study showing that creatine supplementation reduces plasma homocysteine levels. A very promising result.

Stead, L. M. et al. (2001) Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate. American Journal of Physiology – Endocrinology and Metabolism, Volume 281, pages E1095-E1100.

For optimal methylation status combine creatine and B-vitamin supplementation for an accentuated anabolic status (enhanced cellular methylation) and improved overall health (reduced serum homocysteine levels).

How to correctly combine creatine and essential B-vitamins to take full advantage of these very important aspects of creatine supplementation is only discussed in Creatine: A practical guide.

Click here to automatically have a creatine dose calculated to fit your specific needs.

Finally, although the body’s endogenous synthesis of creatine may contribute to elevated homocyteine levels in certain individuals, the importance of creatine in maintaining a positive energy balance cannot be understated. In a sense, creatine synthesis is a necessary evil.

Click here for a more detailed discussion of creatine’s other ergogenic (physical performance enhancing) effects.


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