Creatine Supplementation May Lower Serum Cholesterol Levels

Potential Benefits of Creatine Supplementation Over CHD


Creatine Supplementation May Lower Serum Cholesterol Levels

Preliminary Studies Suggests That Creatine Supplementation Lower Serum Bad Cholesterol Levels

Recent studies have shown that creatine may also improve serum cholesterol profiles by increasing the ratio of good cholesterol (high-density lipoproteins or HDL) to bad cholesterol (low density lipoproteins or LDL) in the blood (Reference 1). Interestingly, this beneficial effect of creatine on blood lipid profiles does not always require a concomitant exercise regimen. A surprising fact given that exercise also exerts a strong protective over blood lipid profiles. It is thus that regular exercise in conjunction with moderate creatine use may prove an effective way to combat coronary heart disease from atherosclerosis in later life.

Interestingly, this positive effect of creatine supplementation on blood lipid profiles may be related to the body’s methylation status. Methylation is one of life’s most important and ubiquitous forms of biochemical regulation. The scope of this biochemical process is all encompassing. Methylation is applied at the levels of our genes as well as is responsible for functionalizing many known growth factors, hormones, neurotransmitters, metabolic mediators (including creatine, adrenaline and carnitine) and structural components of the cell (phospholipids). Indeed, life itself would not be possible without methylation, much less muscle growth.

Methionine Metabolism and Homocysteine

The very important biochemical process of methylation depends on a molecule named SAM, which is derived from the essential amino acid methionine obtained from the diet.


Ironically, despite the profound importance of methylation, exhaustive methylation can lead to the production of a potentially dangerous compound known as homocysteine. Helping neutralize homocysteine may be another area whereby creatine supplementation exerts a positive effect over health (see next section). Most importantly, creatine supplementation has been shown in recent scientific studies to improve the body’s methylation status and hence, mitigate the production of homocysteine(see next page).

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