Creatine & Aggression : Part 1

Is There Evidence for Creatine Causing Aggressive Behavior?

  1. How Might Creatine Use Give Rise to Aggression?
  2. Personal Accounts of Aggression / Mood Swings Following Creatine Use
  3. Possible Correlation Between Brain Creatine Levels and Aggressive Behavior
  4. Scientific Studies Showing an Effect of Creatine Consumption on Mood

How Might Creatine Use Give Rise to Aggression?

Possible sources of aggression sometimes associated with the use of commercial creatine products.

  • Contaminants sometimes present in poorer-quality creatine products.
    Since creatine is classified as a nutritional supplement by the FDA (Food and Drug Administration) it is not held to the same GMP (Good Manufacturing Practices) as the pharmaceutical industry. This relatively innocuous classification, although entirely justified, has opened the way for abuses from certain supplement manufacturers.
    Cases of cross-contamination of nutritional supplements other than creatine monohydrate with anabolic steroids have previously been reported in the scientific literature. It is thus possible that consuming creatine products similarly contaminated with anabolic steroids may give rise to episodes of aggression as well as false positive in drug tests.
  • Impurities produced during the commercial synthesis of creatine.
    Cutting corners while producing creatine in the laboratory can lead to the presence of impurities of laregly unknown toxicity.
  • The use of other nutritional supplements coinciding with creatine use.
    Athletes often “stack” supplements for greater anabolic effects. Therefore, increased aggression may be the result of a prohormone, or other anabolic agent, consumed during a period of creatine supplementation, but independently of a creatine product.

  • The presence of other nutritional supplements sometimes included in commercially available creatine products.
    Commercially available creatine formulations often come combined with other nutritional supplements and/or ergogenic agents. Some of these additives may be derived from anabolic steroids and hence, give rise to secondary side effects including, aggression.
  • Hormonal alterations resulting from creatine use.
    This possible source of aggressive behavior is the most difficult to explain as it implies that creatine supplementation stimulates the synthesis of our steroidal anabolic hormones, which has never been scientifically shown. On the other hand, the presence of contaminants, impurities, or confounding anabolic agents has been demonstrated, which may (under special circumstances) give rise to incidences of increased aggression.

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